MFA Suite™: INCA (ISOTOPOMER NETWORK COMPARTMENTAL ANALYSIS) is a MATLAB-based software package for isotopomer network modeling and metabolic flux analysis. The software can simulate both steady-state and transient isotope labeling experiments using the elementary metabolite unit (EMU) method. It can also estimate pathway fluxes based on extracellular flux measurements, pool size measurements, and/or mass isotopomer measurements supplied to the program. The software can perform a variety of statistical tests to determine goodness-of-fit, to compute parameter confidence intervals (i.e., uncertainty), and to assess model identifiability. It can also perform constraint-based analysis of metabolic networks (e.g., flux balance analysis, flux coupling analysis, etc.) and optimize the design of isotope labeling experiments using computational search algorithms.
Commercial / For-Profit / Non-Academic users should select the Commercial License ($8,500 / year) option.